Servo Driven Vial Powder Filling Machine known as vial dry powder filling machine uses for filling injectable powder into pharmaceutical glass vials. Thick monoblock machine perform filling and stoppering operations on one single machine platform. All contact surface parts of powder made from SS 316L or other FDA approved materials. Machine non contact surface made from SS 304 materials. Bolts and accessories design is aseptic and chosen in which minimum powder residue prevails. Machine comply as per GMP guidelines for pharmaceutical manufacturing. Machine is having servo based mechanism for powder wheel operations in which powder wheel rotates through specific degree set through servo drive. Hence user get precise movement of powder wheel. Stopprting station starwheel also operated through servo drive for smooth operations. Home position of each servo driven mechanism is identified and located in logic, so that every different assembly work together in synchronization.
Adinath is leading vial powder filling machine manufacturers in India produce single powder wheel filling machine and double powder wheel filling machine. We provide IQ, OQ, DQ validation protocols for our equipments. Specific machine models can be offered with 21 CFR Part 11 automation system as per user requirements. We can also offer CE mark machine model as per specific requirements. We provide lifetime support for spare parts for our supplied machines. Machine is having single dosing, double dosing, triple dosing and four dosing features through which one can achieve 250mg to 6 gram fill volume in the vial.
Servo Driven Vial Powder Filling Machine Video
Salient Features of Vial Powder Filling Machine
- Compact GMP Model.
- Suitable to fill 50mg to 1500mg in single dosing.
- Powder wheel rotation and vial transportation through servo motors.
- Vacuum driven specially designed Powder Wheels.
- All contact parts made of SS316L materials with easy removal system for Autoclaving / Sterilization.
- Filling Accuracy of ± 2% depending upon powder characteristics and environmental conditions.
- Built in Rubber Stoppering System.
- Multiple dosing system with the help of change parts.
- Built in Turn Tables with Separate Drive for speed control of infeed and outfeed of vials.
- Various safety features including Clutch system for Vial Breakage.
- Tool Less adjustment of Doctor Blade and Wiper Blade saves valuable time and easy for setting.
- IQ/OQ Validation documentation can be provided.
- PLC system with Graphical User Interface can be offered.
- Inbuilt Laminar Air Flow can be offered for sterile class 100 filling.
- Sampling and Rejection system can be provided on demand.
Process Operation of Vial Powder Filling Machine
The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having twelve ports which rotates at pre-determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided. There is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked into the port of powder wheel during vacuum; according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one.
The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation.
The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further container is passed between two pressing roller for tight fit fixing of rubber stoppers.
Technical Specification of Vial Powder Filling Machine
| Models | APF 12S | APF 12D |
| Production Output | Up to 100 vials/minute | Up to 200 vials/minute |
| Fill Volume | 50 mg. to 10grams | 50 mg. to 10 grams |
| Vial Size | 5ml to 250ml | 5ml to 250ml |
| Filling Accuracy | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder |
| Power Load | 3.5 H. P. | 4.5 H. P. |
| Overall Dimension | 2600mm (L) X 1100mm (W) X 1800mm (H) approx. | 3000mm (L) X 1100mm (W) X 1800mm (H) approx. |
| Net Weight | 500 kgs. approx. | 700 kgs. approx. |
| Gross Weight | 750 kgs. approx. | 950 kgs. approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
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