Closed Ampoule Filling Machine, also known as a closed ampoule filler, has a strong construction and an intuitive design. To achieve GMP compatibility, contact areas of sterile liquid composed of SS 316L material. A single platform is used to carry out the ampoule opening, filling, and sealing processes in this monoblock design. For cGMP compliance, contact areas of sterile liquid composed of AISI SS 316L material. The number of filling nozzles is determined by the output needed and the selected model.
Suitable machine for 1 ml to 10 ml glass ampoules. It can even fill large ampoules up to 30 ml in certain variants. The machine can fill between 0.5 and 30 milliliters in a single dosage. The equipment can fill up to 250 ampoules per minute using various model options. We provide a variety of filling mechanism options, the most popular being peristaltic pump filling, servo controlled filling, and piston pump filling.
Closed ampoule filler and sealer designed to precisely fill a wide variety of injectable liquids. The ampoule is transferred by slanting the rack, and activities such as nitrogen purging, liquid filling, preheating, sealing, and collection are carried out throughout the movement. No ampoule – no liquid feature integrated by default to reduce liquid waste.
Being a top producer of closed ampoule filling machines, we offer reliable equipment with easy-to-maintain designs. One of India’s top exporters of closed ampoule filling machines is Adinath International. We have Single, Two, Four, Six, and Eight Head variants of the Closed Mouth Ampoule Filling Machine available.
CLOSED AMPOULE FILLING MACHINE VIDEO
Salient Features of Closed Ampoule Filling Machine
- Compact cGMP model.
- Higher output up to 12000 Ampoules per hour.
- All contact parts made from High Quality Stainless Steel 316L & Non-contact parts made from Stainless Steel 304.
- Minimum change over parts from 1ml to 10ml ampoule size.
- “No Ampoule – No Filling” system.
- Ampoule neck centering during gas flushing and filling operations.
- Possibility of nitrogen gas flushing before, during and after filling.
- Full accessibility allows easy maintenance.
- Machine equipped with pre-warming station.
- Flow Meters for regulating flames easily.
- Minimum change over time, little maintenance, easy cleaning.
Types of Closed Ampoule Filling Machine
- Single Head Closed Ampoule Filling Machine
- Two Head Closed Ampoule Filling Machine
- Four Head Closed Ampoule Filling Machine
- Six Head Closed Ampoule Filling Machine
- Eight Head Closed Ampoule Filling Machine
- Servo Driven Closed Ampoule Filling Machine
- Peristaltic Pump type Closed Ampoule Filling Machine
- High Speed Closed Ampoule Filling Machine
Process Operation of Closed Ampoule Filling Machine
Closed mouth/pre sterilized ampoules loaded onto infeed hopper of the machine. From where it has been received to receiving rack through starwheel/cassette. The moving rack which moves horizontally collect one/two/four/eight ampoules from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position. During ampoule movement sequentially below operations performed:
- Pre-gassing with Nitrogen
- Filling the product
- Post Gassing with Nitrogen
- Pre-heating with LPG & Oxygen combination
- Sealing with LPG & Oxygen combination
At the end duly filled and sealed ampoules get collected automatically onto collection tray of the machine. Ampoules now can be collected for further inspection and/or sticker labeling operations.
Technical Specification of Closed Ampoule Filling Machine
| Model | AFS-1C | AFS-2C | AFS-4C | AFS-8C |
| No. of Head | Single | Two | Four | Eight |
| Syringes | One | Double | Four | Eight |
| Ampoule Sizes | 1 ml to 30 ml | 1 ml to 30 ml | 1 ml to 20 ml | 1 ml to 20 ml |
| Filling Speed | Up to 25 ampoules/minute | Up to 50 ampoules/minute | Up to 100 ampoules/minute | Up to 200 ampoules/minute |
| Filling Precison | ± 1% | ± 1% | ± 1% | ± 1% |
| Filling Pump | Piston Pump | Piston Pump | Piston Pump | Piston Pump |
| Burner Gas | LPG & Oxygen (O₂) | LPG & Oxygen (O₂) | LPG & Oxygen (O₂) | LPG & Oxygen (O₂) |
| Nitrogen Arranegment | Before & After Filling | Before & After Filling | Before & After Filling | Before & After Filling |
| Number of Fill Nozzles | One | Two | Four | Eight |
| Number of Nitrogen Nozzles | Two | Four | Eight | Sixteen |
| Number of Sealing Burners | Two | Four | Eight | Sixteen |
| Power Required | 0.5 H.P. | 1 H.P. | 1 H.P. | 2 H.P. |
| Power Voltage | 230 Volts, Single Phase, 50 Hertz, 4 Wire System | 230 Volts, Single Phase, 50 Hertz, 4 Wire System | 230 Volts, Single Phase, 50 Hertz, 4 Wire System | 230 Volts, Single Phase, 50 Hertz, 4 Wire System |
| Contact Parts | Made from Stainless Steel 316L | Made from Stainless Steel 316L | Made from Stainless Steel 316L | Made from Stainless Steel 316L |
| Overall Dimension | 1050mm (L) x 610mm (W) x 965mm (H) approx. | 1150mm (L) x 760mm (W) x 965mm (H) approx. | 1400mm (L) x 1070mm (W) x 965mm (H) approx. | 2700mm (L) x 1400mm (W) x 1100mm (H) approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
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