Pharmaceutical Machinery Manufacturers in India

Tablet Production Line

Sieving, Blending, Milling, Drying, Granules Forming, Lubrication, Tablet Compression, and Tablet Blister Packaging Machines are all part of the Tablet Production Line (Tablet Processing Line), which includes the Tablet Manufacturing Line. Both dry and wet granulation tablet production lines are available from us. Every machine satisfies cGMP standard production specifications. The Adinath series provides both a High-Speed Tablet Production Line and a Small Tablet Production Line.

Tablet Production Line

Compressed powdered, crystalline, or granular active materials (API) can be used alone or in combination with other exponents as needed, such as lubricants, diluents, flavors, and colorants, binders, disintegrants, and prolonged release polymers, to make tablets. Wet granulation, dry granulation, and direct compression are the three main processes that make up the tablet production process. The process you should choose depends on the type of product you are manufacturing. We have included detailed information on each of the three tablet production processes below:

Wet Granulation

The most popular technique for preparing tablets is this one. This approach uses “adhesion” to bind the powders to a suitable binder. Before adding the binder to the blended powders, it is diluted with a suitable solvent to create wet granules. These granules are then dried appropriately to remove the solvent, creating dried granules. The initial generation of granules is mainly caused by surface tension forces and capillary pressure. The primary benefit is that, despite being multistage and time-consuming, it satisfies all requirements for tablet formation.

Dry Granulation

Granules can be formed without the need of a liquid solution by employing the dry granulation technique. This kind of procedure is advised for goods that are heat-and moisture-sensitive. Compressing and solidifying the powders is necessary to form granules without the need for moisture. Slugging tooling can be used on a tablet press for dry granulation. Powder compacting is a frequent term for large-scale roller compactors. Slugging is the process of compacting a mass that is referred to as slugs. The slugs are further processed or screened to create tablet materials in granular form with better flow characteristics than the original powder mixture. The primary benefit of dry granulation is that it requires less equipment and does not require heat or moisture addition, unlike the wet granulation method’s drying and wet massing stages. Oral solid dosage forms, like tablets, are made by a multi-stage, intricate process that requires several physical changes from the beginning components to the finished dosage form. Granulation is a traditional method of making tablets, which imparts two essential requirements for formulation: compactibility and fluidity. Slugging and roll compaction, or wet and dry granulation, are both employed. The initial phase, milling and mixing, is the same whether tablets are formed by direct compression or granulation; the remaining steps vary. Making tablets involves a number of unit operations, such as sizing and reducing the size of the particles, blending, granulating, drying, compaction, and (sometimes) coating. A number of variables related to these processes have the potential to significantly impact stability, bioavailability, and content homogeneity.

Direct Compression

Without changing the physical makeup of the ingredients, the powdered elements are compressed directly to create the tablets. For crystalline materials with good physical qualities like flow and compressibility, direct compression is typically used. The main benefits of direct compression are its low cost, safety of operation, and time saving.

Tablet Production Line generally consist below mentioned functions and equipment’s. We are giving here below step-by-step tablet processing flow chart with machine details:

STEP 1 – Powder- Raw Material
STEP 2 – Grading & sieving Process (Machine – Vibro Sifter)
STEP 3 – Dry & Wet mixing with binder (Machine –High Shear Mixer OR Mass Mixer)
Starch Paste Preparation (Machine-Paste Making Kettle)
STEP 4 – Lumps Milling (Machine Multi mill / Cone Mill/Comminuting Mill / Oscillating Granulator)
STEP 5 – Wet Material Drying (Machine – Fluid Bed Drier OR Tray Dryer Oven)
STEP 6 – Forming Granules (M/c Multi mill / Cone Mill/Comminuting Mill / Oscillating Granulator)
STEP 7 – Grading & sieving (Machine – Vibro Sifter)
STEP 8 – Lubrication of granules for free flowing (M/c Blender Octagonal / Double & V Cone, Bin)
STEP 9 – Tablet Compression (Machine – Tablet Press & Die & Punch
STEP 10 – Tablet De Dusting (Machine – Vibro De Duster)
STEP 11 – Powder dust extracting during tablet compression (Dust Extractor Unit)
STEP 12 – Film & Sugar Coating of tablets (Machine – Auto Coater or Conventional coating)
Coating solution preparation (Machine – Stirrer & Colloid Mill)
STEP 13 – After That Tablets will be inspected and Packed.

Vibro Sifter

A vibrating motor and a circular pre-tensioned screen set on a frame make up the Vibro Sifter, also known as a vibrating sieve unit. Because of the eccentric weights rotating in three planes, the vibrating motor causes vibrations in the screen. The entire assembly is supported by the appropriate springs, allowing it to vibrate as an independent body without sending any vibrations to the foundations.

Rapid Mixer Granulator

The Rapid Mixer Granulator is engineered to minimize processing time, provide more uniform and homogenous granule mixing at lower operating costs, and, most importantly, maintain better sanitary compliance with cGMP standards. The functioning principles of the Rapid Mixer Granulator are predicated on two critical elements that are necessary for the intimate mixing mechanism. 1. Spinning near the bottom of the mixing bowl; 2. The impeller causes the mixture to rise in a whirl.

Multi Mill

A portable, self-contained device called Multi Mill can chop, shred, combine, and granulate a variety of wet and dry materials quickly and efficiently without the need for additional accessories. This machine uses the principle of variable force swing hammer blades with both knife and impact edges rotating with a carefully chosen screen to control size reduction, as opposed to the four common principles of size reduction—grinding, compression, impact, and shearing—which frequently do not produce controlled size reduction. The material flow path in a vertical rotor machine is optimized. In order to prevent chocking and temperature rise during comminution, material entering the chamber moves to the periphery and passes through the screen tangentially and radially.

Fluid Bed Dryer

The purpose of fluid bed dryers is to evenly dry materials at low temperatures. GMP-compliant stainless steel 304/316 is used to make fluid bed dryers. A suitable motor, blower, filters, filter bag, and control panel are included with the entire machine. Heating system supplied in accordance with particular client specifications.

Octagonal Blender

Granular items can be mixed with an octagonal blender (octagonal mixer), which also includes an octagonal-shaped equipment. The equipment is easy to clean and maintain, and it gives a great deal of operational versatility. The machine’s functionality is further enhanced by its straightforward construction and GMP-compliant design. An effective and adaptable blending tool for uniformly mixing and lubricating dry granules is the Octagonal Blender. To guarantee adequate mixing, fill the Cone Blender to two thirds of its capacity.

Tablet Compression Machine

Single and double rotary tablet presses with hygienic features are available in our selection of tablet compression machines. Commonly used for slugging large tablets, our Square GMP Model is also known as a single and double rotational tablet press machine. Based on the needs of the chemical and pharmaceutical industries, we design 8 station rotary tableting machines, 10 station rotary tableting machines, 12 station rotary tableting machines, 16 station rotary tableting machines, 27 station rotary tableting machines, and 35 station rotary tableting machines.

Blister Packaging Machine

The tablets and capsules are packaged in blister packs using an automatic blister packaging machine. The pharmaceutical sector, regardless of size, can benefit greatly from our machines due to their exceptional quality, dependability, performance, and affordability.