Automatic Ampoule Filling and Sealing Machine

The Automatic Ampoule Filling and Sealing Machine is designed to fill and flame‑seal glass ampoules in an uninterrupted flow process. It is apt for pharmaceutical, biotech, cosmetic and speciality chemical industries. It handles sizes ranging from 1 ml diagnostic doses to 30 ml injectable preparations, protecting each batch with inline nitrogen flushing and cGMP-compliant stainless steel construction. The machine transforms loose ampoules into hermetically sealed units. Whether you produce pilot lots or high-volume injectables. It ensures each product is ready for inspection or labelling, while keeping particles and operator contact away from the sterile zone.

Automatic Ampoule Filling and Sealing Machine Video

Types of Ampoule Fillers

• Small Ampoule Filler

• Ampoule Filler and Sealer

• Onion Skin Ampoule Filler

• Servo Driven Ampoule Filler

• Peristaltic Pump type Ampoule Filler

• Closed Ampoule Filler

• Single Head Ampoule Filler

• Two Head Ampoule Filler

• Four Head Ampoule Filler

• Six Head Ampoule Filler

• Eight Head Ampoule Filler

Durable Build, High‑Speed Performance, ±1 % Accuracy

The Automatic Ampoule Filling and Sealing Machine, with a sturdy stainless‑steel 304 frame and 316L contact parts, offers long life in a clean‑room environment. Its flame‑proof guards and a pre‑warming station protect the operator and product. The single, two, four or eight head models deliver 1,500 to 12,000 ampoules per hour (from 1ml to 259ml sizes) at ±1% fill accuracy. You can select piston, servo‑driven piston, or peristaltic pumps and adjust the volume from the touch screen in seconds. Few change parts, “NoAmpoule–NoFill” sensors and nitrogen purging before, during and after filling work together to reduce rejects, minimise changeovers, and ensure every dose remains oxygen-free.

How Does the Ampoule Filling and Sealing Machine  Work

1. Bulk Feed – Operators tip empty ampoules into the hopper; a star‑wheel indexes them onto the slanted transport rack.

2. Nitrogen Pre‑Flush – The first nozzle injects inert gas to displace air.

3. Precision Fill – The second nozzle dispenses liquid; servo or piston control holds volume within ±1 %. “No Ampoule–No Fill” logic prevents spills.

4. Nitrogen Post‑Flush – A third nozzle blankets the product to stop oxidation.

5. Pre‑Heat – Ampoules pass a low‑flame burner that dries stray droplets and warms glass for uniform sealing.

6. Flame Seal – A stronger burner melts the neck; spinning holders rotate the ampoule for an even dome while clippers drop waste glass into a tray.

7. Discharge – Filled, sealed ampoules stand upright on an SS tray, ready for inspection or downstream labelling.

Key Features

• Compact, cGMP design fits isolators or LAF benches.

• Output up to 200 ampoules min⁻¹ with the eight‑head model.

• All contact parts in 316L stainless; non‑contact parts in 304 stainless for easy wipe‑down.

• “No Ampoule–No Fill” and neck‑centring devices cut breakage.

• Nitrogen flushing before, during, and after filling prolongs product life.

• Flow‑metered burners and a pre‑warming station ensure perfect glass domes.

• CE‑marked and 21 CFR Part 11 options support global compliance.

Technical Specification of Ampoule Filling and Sealing Machine

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

The Automatic Ampoule Filling and Sealing Machine gives you a single, reliable platform to wash away oxygen, fill with pinpoint precision, and flame‑seal at high speed; all while protecting staff and product. Its stainless build, flexible pump options, and intuitive controls minimise maintenance, maximise uptime, and keep regulators satisfied. Choose the head count that matches your batch size, plug it into your line, and send perfectly sealed ampoules to market with confidence.